منابع مشابه
Phagocytosis and the actin cytoskeleton.
The process of engulfing a foreign particle - phagocytosis - is of fundamental importance for a wide diversity of organisms. From simple unicellular organisms that use phagocytosis to obtain their next meal, to complex metazoans in which phagocytic cells represent an essential branch of the immune system, evolution has armed cells with a fantastic repertoire of molecules that serve to bring abo...
متن کاملSWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis
Actin plays a critical role during the early stages of pathogenic microbe internalization by immune cells. In this study, we identified a key mechanism of actin filament tethering and stabilization to the surface of phagosomes in human dendritic cells. We found that the actin-binding protein SWAP70 is specifically recruited to nascent phagosomes by binding to the lipid phosphatidylinositol (3,4...
متن کاملMINIREVIEW / MINISYNTHÈSE Phagocytosis and the microtubule cytoskeleton
Phagocytosis is a critical host defense mechanism used by macrophages and neutrophils to clear invading pathogens. The complex sequence of events resulting in internalization and degradation of the pathogens is a coordinated process involving lipids, signaling proteins, and the cytoskeleton. Here, we examine the role of the microtubule cytoskeleton in supporting both the engulfment of pathogens...
متن کاملVisualising the actin cytoskeleton.
The actin cytoskeleton is a dynamic filamentous network whose formation and remodeling underlies the fundamental processes of cell motility and shape determination. To serve these roles, different compartments of the actin cytoskeleton engage in forming specific coupling sites between neighbouring cells and with the underlying matrix, which themselves serve signal transducing functions. In this...
متن کاملThe Bacterial Actin Cytoskeleton
M icrobial shape, long used as a taxonomic criterion, is genetically determined. But how DNA sequence information is translated into morphology is a seminal question still without a complete answer for any microorganism. Recently, however, when investigators discovered that actin-like proteins are involved in determining bacterial cell shape, they revolutionized the field. This insight provides...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2001
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.114.6.1061